Advances in Research and Applications by G.D. Aurbach and Donald B. Mccormick (Eds.)

By G.D. Aurbach and Donald B. Mccormick (Eds.)

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Recent reviews include that of Rothwell and Stock (1983), with a dissenting view by Hervey and Tobin (1983) and by Himms-Hagen (19841, which provoked a rebuttal (Seaton and Welle, 1985) and counterrebuttal (Himms-Hagen, 1985). It is because there has been so much disagreement between results of studies from competent laboratories that I have examined the available reports in some detail in the hope of finding sources of the discrepancies which may be taken into consideration in future studies. I believe that the bulk of the most reliable evidence favors a facultative component to diet-induced thermogenesis in normal man and that the main sources of contradictory results lie in the heterogeneity of the subjects and in certain limitations of the methods and protocols employed.

4%. Overfeeding did not 42 ETHAN A. H. SIMS affect the thermic effect of a standard meal, which was measured, however, only over a 2-hour period, nor did it affect the response to infusion of norepinephrine. Catecholamines were not increased in plasma or urine, and propranolol, given to block p-adrenergic stimulation, produced the same effect on oxygen uptake after as before the overfeeding. Neither was there an increase in thermic effect of a standard meal after overfeeding. These findings were consistent with those of Katzeff et al.

In contrast to obese women, they appropriately increased intake to maintain their usual weight. Resting metabolic rate and the thermic response to food are increased for a period after strenuous exercise. Beilinski et al. (1985) measured energy expenditure for a 42-hour period in the chamber at Lausanne. 7% elevated. A mixed meal given 4 hours after exercise induced a greater fraction of lipid oxidation and persisted to the following day. Devlin and Horton (1985) measured the thermic response to infused insulin at two concentrations using the euglycemic clamp procedure in normal untrained subjects 12-16 hours after exercise t o exhaustion.

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